525 Protein A/Prosorba
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Partial monograph text:
Prosorba Column; Immunosorba Column; Protein A affinity chromatography of blood plasma Status: approved; marketed Organizations involved: Cypress Bioscience, Inc. - R&D; Tech.; USA mark. Fresenius HemoCare, Inc. - Manuf. Fresenius Hemotechnology, Inc. - World mark. Fresenius AG - Parent Medexus, Inc. - Canada mark. IMRE Corp. - Former Baxter Healthcare Corp. - Former Description: The Prosorba Column is a single-use cylindrical polycarbonate (plastic) extracorporeal plasma filtration column containing an affinity chromatography matrix of nonrecombinant Staphylococcus aureus (S. aureus) Protein A obtained from culture of S. aureus bacteria covalently bound to inert silica granules. The Prosorba Column is used in conjunction with a plasmapheresis (blood filtration) device for the selective removal of antibodies, particuarly clusters of circulating immune complexes (CICs; antibody-antigen clusters) that contribute to immune dys-regulation from a patient's blood plasma, with CICS removal resulting in stimulation of the patient's immune responses. After passing a patient'sblood through the extracorporeal (external) plasmapheresis device, which separates plasma (the fluid component of whole blood), and ... truncated (just the beginning) |
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