Status: marketed in Europe, Australia and other countries; not approved in the U.S.

Organizations involved:

GlaxoSmithKline Biologicals S.A. (GSK) – Manuf.; R&D; Tech.;

GlaxoSmithKline plc (GSK) – Europe mark.; Parent

Cross ref: See the entry for M-M-R II, the comparable vaccine distributed in the U.S. and the entries for similar related component vaccines – Measles Virus Vaccine Live (Attenuvax); Rubella Vaccine Live (Meruvax II), and Mumps Virus Vaccine Live (Mumpsvax).

Description: Priorix is a lyophilized formulation combining three live vaccines: 1) Measles Virus Vaccine Live, an attenuated live measles virus derived from Schwarz' strain and propagated in chick embryo cell culture; 2) Mumps Virus Vaccine Live, RIT 4385, a type of Jeryl Lynn mumps virus strain propagated in chick embryo cell culture; and 3) Rubella Virus Vaccine Live, Wistar RA 27/3 strain of live attenuated rubella virus propagated in human diploid MRC-5 cells. After mixing with the water, each 0.5 ml dose contains not less than the following amounts of each virus type: 10.sup.3 CCID.sub.50 measles virus (Schwarz strain), 10.sup.3.7 CCID 50 mumps virus (RIT 4385 strain) and 10.sup.3 CCID.sub.50 rubella virus (RA 27/3 strain).

Priorix also contains the inactive ingredients lactose, sorbitol (E420), and the following amino acids; L-alanine, L-arginine, glycine, L-histidine, L-isoleucine, L-leucine, L-lysine HC1, L-methionine, L-phenylalanine, L-proline, L-serine, L-threonine, L-tryptophan, L-tyrosine, L-valine, L-aspartic acid, L-cysteine, L-cystine, L-hydroxproline, and mannitol. Priorix may contain very small amounts of neomycin sulfate. Priorix is stored at 2-8˚C (refrigerated). The shelf-life of Priorix is two years.

Companies.: Priorix is manufacture by

Indications: [full text of the "Therapeutic indications:" section of the SPC]:

Priorix is indicated for active immunisation against measles, mumps and rubella.

Status: Approved and marketed in various European countries. Approved in the U.K. in 1997. Not approved through centralized EU/EMEA regulation.